Siegfried Mureşan was born in Hunedoara, Romania to a German mother and a Romanian father. In 2004, he graduated from the Academy of Economic Studies in Bucharest. He continued his studies with a Masters in Economics and Management Science at Humboldt University in Berlin. In 2006 he received a scholarship from the German Parliament and was part of the Bundestag’s International Internship Programme. Subsequently, he continued for three years as an Advisor to the Chairman of the Committee on European Affairs of the German Parliament, Gunther Krichbaum.
In 2009, he moved to Brussels where he initially worked in the European Parliament. In 2011, he joined the Headquarters of the European People's Party as Political Advisor for Economics and Social Policy. In January 2014, he was promoted to Senior Political Advisor. His responsibilities at the EPP included the coordination of EPP Ministerial Meetings ahead of ECOFIN, Competitiveness, Employment and General Affairs Councils.
MEP since 2014.