Therese Comodini Cachia graduated in law in 1997 and holds a Ph.D. in human rights law. She is a lawyer by profession working in the field of human rights. She has been representing victims of human rights violations since 1997 through court proceedings both before the Maltese courts as well as before the European Court of Human Rights.

She has also been heavily involved in NGOs having acted as their legal advisor. Her work with NGOs has kept her abreast of the perceptions held by and the social needs of different groups in society.

She is a lecturer at the Faculty of Laws of the University of Malta and coordinates the Master's Degree in Human Rights and Democratisation. She also lectured at the University of Utrecht in Holland and currently lectures at the Europa-Viadrina University in Germany.

Comodini Cachia has actively participated in the Partit Nazzjonalista and was a member of the Commission for the revision of the Statute and Party Structures. She is also seen as a point of reference for the Parliamentary Group having contributed to a number of positions including amendments to the Constitution of Malta.

MEP since 2014.